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-synuclein, which is a major component of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, and that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) tension, recommend that dysfunction of the intracellular proteinase devices, such as ubiquitin-proteasome technique or lysosomal process, which eliminates pointless toxic p
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